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Securing Library Books Theft and Mutilation in University of Uyo through Electronic Detection Systems
(Management of Library and Information Centres in the Era of Global Insecurity, 2020) Idogbe, Ibukunoluwa Moses
LIBRARIES AND INFORMATION LITERACY FOR NATIONAL DEVELOPMENT
(Nigerian Library Association, Akwa Ibom State Chapter, 2019) Idogbe, Ibukunoluwa Moses
Knowledge or information they say is power. For any nation to develop, the rate of information literacy within such nation must be very high. Abu Abu, Isah, Oyedum & Bitagi (2017) states that national development could mainly be achieved by well responsible and intellectual citizens, because all sectors of government like social, economic, human capacity, agriculture and health are supposed to impact positively on the lives of individuals. The authors add that it is important to note that the quality of man power that possess technical know-how to improve the standard of living depend solely on the availability of information. Therefore, information plays a vital role in achieving sustainable knowledge development of all citizens
Library Book Theft, Mutilation, and Detection Mechanisms in University of Uyo Library
(Benue Journal of Library, Management and Information Science (BJLMIS), 2024-06) Idogbe, Ibukunoluwa Moses
Ascorbic and Salicylic Acids Modulate the Binding Interactions of an Emergency Contraceptive Pill Levonorgestrel to a Model Transport Protein: Insights from Spectroscopy and Molecular Docking Analysis
(Elsevier, 2023-10-11) Oyetunde Temidayo
Serum proteins generally help to transport and distribute drug molecules within the body. In this study, the binding characteristics of bovine serum albumin (BSA) with levonorgestrel (LVG), an emergency contraceptive pill, and the influences of ascorbic acid (ASC) and salicylic acid (SAL) on the binding behaviour and protein structure were elucidated using multi-spectroscopic techniques and molecular docking. The results showed that levonorgestrel decreased BSA intrinsic fluorescence via static quenching mechanism. Binding constant (Ka) values for BSA-LVG complexes were 103 to 104 M-1, indicating their high stabilities. Site probing/docking analysis indicated LVG bound between BSA subdomains IIA and IIIA. UV–visible absorption, Fourier Transform- Infrared and 3D fluorescence spectroscopies affirmed LVG-induced changes in BSA structure, especially in α-helix and β-sheet contents. ASC and SAL influenced BSA conformation for LVG binding and reduced the Ka values by 3.37 and 5.43-folds, respectively. LVG altered the microenvironments of tyrosine residues, interacted with Arg- 217, Lys-221, Val-292, Glu-443 etc. within the binding domains. The process was spontaneous (ΔG<0), entropy driven (TΔS>ΔH) and involved van der Waals forces and hydrogen bonding. The findings of the study offered details on the binding interaction between BSA and LVG, and also indicated that prior intake of ASC or SAL could suppress the binding affinity of BSA for levonorgestrel.
Cadmium-Induced Adverse Alteration of Reproductive Parameters and Testicular Histoarchitecture of Wistar Rats Protective Role of Palmitic Acid
(ANNALS OF HEALTH AND ALLIED SCIENCES, 2025-02-08) Daramola Oore-oluwapo Ololade
Cadmium (Cd) generates reactive oxygen species (ROS), leading to oxidative stress and adversely affecting reproductive organs and functions. Conversely, palmitic acid (PA) is a free radical scavenger naturally found in palm oil and consumed in diets. This study investigated the protective role of PA against cadmium-induced adverse alteration of male Wistar rats’ reproductive parameters. Twenty mature male Wistar rats were grouped into four (n=5/group): 0.2 mL of 10% Tween 80 (Control); 2 mg/kg bw-Cd; 2 mg/kg bw - Cd+200 mg/kg bw PA; and 200 mg/kg bw PA. PA was given via oral route daily for thirty days, while a single dose of Cd was intraperitoneally given. Serum testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH); testicular concentrations of magnesium, calcium, zinc, and cadmium; epididymal sperm parameters (morphology, motility, viability, and counts) were evaluated, and the testicular histoarchitecture was assessed using standard techniques. Data obtained were statistically analysed and compared using ANOVA at p < 0.05. In comparison to the control group, Cd exposure significantly decreased serum testosterone, FSH, and LH levels; testicular magnesium, calcium and zinc; sperm motility, viability and counts. In addition, cadmium exposure resulted in abnormal sperm morphology and distorted testicular histoarchitecture. The co-administration of Cd and PA in group 3 showed significant reversal of the adverse effect of Cd on reproductive hormones, electrolytes, sperm parameters and testicular histomorphology. Hence, palmitic acid exhibits a protective effect against cadmium-induced adverse alterations of reproductive parameters and testicular histoarchitecture in Wistar rats.